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Cardiovascular–kidney–metabolic (CKM) syndrome is a term coined to highlight the close associations among type 2 diabetes mellitus (T2DM), obesity, renal disease and cardiovascular disease (CVD) and to enhance an integrated clinical care model for patients. The novel framework proposed by the American Heart Association (AHA) is a paradigm shift in the management of multimorbidity in […]

Domenica M. Rubino, ENDO 2021: Findings from the STEP 4 Study

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Published Online: Apr 13th 2021

It was a pleasure to talk to Dr Domenica Rubino (Washington Center for Weight Management and Research, Arlington, VA, US) around the effect of once-weekly semaglutide on weight loss maintenance in overweight or obese adults.

‘Weight Loss Maintenance With Once-Weekly Semaglutide 2.4 MG in Adults With Overweight or Obesity Reaching Maintenance Dose (STEP 4).‘ (PRESENTATION NUMBER: OR02-3) was presented at the ENDO 2021 Virtual Annual Meeting, March 20 – 23, 2021.

Questions

  1. What are the current unmet needs in the management of adults with obesity? (0:13)
  2. What was already known about the weight loss benefits of semaglutide in people with obesity? (2:13)
  3. What were the aims and design of the STEP 4 study, and what were the findings? (3:16)
  4. What were the safety findings of this study? (4:55)
  5. What have we learned about the need for long-term treatment with semaglutide? (6:54)

Disclosures: Clinical investigator for NovoNordisk, Boehringer Ingelheim and Astra Zeneca; speaker, consultant and shareholder for NovoNordisk; received speaker honoraria from WebMD/Medscape; grant recipient of Obesinov SARL.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of ENDO 2021 (Virtual).

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