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Hyponatraemia is primarily a disorder of water balance or distribution, characterized by serum sodium (Nas) levels less than 135 mmol/L.1 Hyponatraemia is the most common electrolyte disorder among elderly patients and is associated with increased mortality rates and longer hospital stays.2–4 The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a frequent cause of hyponatraemia in […]

Domenica M. Rubino, ENDO 2021: Findings from the STEP 4 Study

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Published Online: Apr 13th 2021

It was a pleasure to talk to Dr Domenica Rubino (Washington Center for Weight Management and Research, Arlington, VA, US) around the effect of once-weekly semaglutide on weight loss maintenance in overweight or obese adults.

Weight Loss Maintenance With Once-Weekly Semaglutide 2.4 MG in Adults With Overweight or Obesity Reaching Maintenance Dose (STEP 4).‘ (PRESENTATION NUMBER: OR02-3) was presented at the ENDO 2021 Virtual Annual Meeting, March 20 – 23, 2021.

Questions

  1. What are the current unmet needs in the management of adults with obesity? (0:13)
  2. What was already known about the weight loss benefits of semaglutide in people with obesity? (2:13)
  3. What were the aims and design of the STEP 4 study, and what were the findings? (3:16)
  4. What were the safety findings of this study? (4:55)
  5. What have we learned about the need for long-term treatment with semaglutide? (6:54)

Disclosures: Clinical investigator for NovoNordisk, Boehringer Ingelheim and Astra Zeneca; speaker, consultant and shareholder for NovoNordisk; received speaker honoraria from WebMD/Medscape; grant recipient of Obesinov SARL.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of ENDO 2021 (Virtual).

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