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Type 2 diabetes (T2D) is a progressive metabolic condition associated with obesity, cardiovascular disease and substantial morbidity and mortality.1 Despite the availability of multiple glucose-lowering therapies, a significant proportion of individuals with T2D fail to achieve recommended glycemic targets, particularly those with long disease duration, obesity and insulin resistance.2,3 In parallel, excess adiposity remains a major driver of […]

Camilo Jimenez, ENDO 2021: The Role of Tumour Biomarkers in the use of I-131MIBG

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Published Online: May 26th 2021

It was a pleasure to talk to Professor Camilo Jimenez (The University of Texas MD Anderson Cancer Center, Houston, TX) around biochemical tumour markers in the use of I-131-labeled MIBG for pheochromocytoma and paraganglioma.

‘Biochemical Tumor Marker Status and Its Role in Treatment Response in Patients Who Received High-Specific-Activity I-131 MIBG in Advanced Pheochromocytoma and Paraganglioma (PPGL): Results From a Pivotal Phase 2 Clinical Trial’ (PRESENTATION NUMBER: OR04-3) was presented at the ENDO 2021 Virtual Annual Meeting, March 20 – 23, 2021.

Questions

  1. What role are tumour biomarkers likely to play in the future use of I-131MIBG in this patient population? (0:22)
  2. What will be the next step in the clinical development of I-131 MIBG? (2:40)

Disclosures: Professor Camilo Jimenez is a principal investigator of phase 2 and phase 4 clinical trials with high specific activity MIBG for patients with metastatic pheochromocytomas and paragangliomas and has received research support from Lantheus Pharmaceuticals.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Victoria Jones.

Filmed as a highlight of ENDO 2021 (Virtual).

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