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Thyroid gland inside human body. 3D illustration
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Thyroid eye disease (TED), also known as Graves’ orbitopathy, is a complex autoimmune disorder driven by an interplay of immune cells, orbital fibroblasts and tissue remodelling factors that lead to inflammation, oedema and, ultimately, potential vision loss.1 While the disease has historically been challenging to manage, recent therapeutic innovations are reshaping treatment paradigms and offering new […]

Camilo Jimenez, ENDO 2021: The Role of Tumour Biomarkers in the use of I-131MIBG

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Published Online: May 26th 2021

It was a pleasure to talk to Professor Camilo Jimenez (The University of Texas MD Anderson Cancer Center, Houston, TX) around biochemical tumour markers in the use of I-131-labeled MIBG for pheochromocytoma and paraganglioma.

‘Biochemical Tumor Marker Status and Its Role in Treatment Response in Patients Who Received High-Specific-Activity I-131 MIBG in Advanced Pheochromocytoma and Paraganglioma (PPGL): Results From a Pivotal Phase 2 Clinical Trial’ (PRESENTATION NUMBER: OR04-3) was presented at the ENDO 2021 Virtual Annual Meeting, March 20 – 23, 2021.

Questions

  1. What role are tumour biomarkers likely to play in the future use of I-131MIBG in this patient population? (0:22)
  2. What will be the next step in the clinical development of I-131 MIBG? (2:40)

Disclosures: Professor Camilo Jimenez is a principal investigator of phase 2 and phase 4 clinical trials with high specific activity MIBG for patients with metastatic pheochromocytomas and paragangliomas and has received research support from Lantheus Pharmaceuticals.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Victoria Jones.

Filmed as a highlight of ENDO 2021 (Virtual).

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