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Forty-four Years of the UK Prospective Diabetes Study: Legacy Effect and Beyond

Saptarshi Bhattacharya, Sanjay Kalra, Lakshmi Nagendra

Very few trials in the history of medical science have altered the treatment landscape as profoundly as the UK Prospective Diabetes Study (UKPDS). Even 44 years after its inception, the trial and post-study follow-up findings continue to fascinate and enlighten the medical community. The study was conceived at a time when there was uncertainty about […]

touchREVIEWS in Endocrinology. 2024;21(1):1–2:Online ahead of journal publication

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Inflammation, Oxidative Stress, and the Metabolic Syndrome

Ishwarlal Jialal, Rajeev Goyal, Sridevi Devaraj
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Published Online: Jun 6th 2011 US Endocrinology, 2008;4(2):32-7 DOI: http://doi.org/10.17925/USE.2008.04.2.32
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1

Abstract

Overview

Metabolic Syndrome
The metabolic syndrome (MetS) comprises a cluster of metabolic abnormalities with insulin resistance and adiposity as its central features, which confer an increased propensity to diabetes and cardiovascular disease (CVD). The metabolic abnormalities include central obesity, dyslipidemia (high triglycerides, low high-density lipoprotein [HDL]), hypertension, and impaired fasting glucose (IFG). Five diagnostic criteria have been identified by the Adult Treatment Panel III (ATP-III) and the presence of any three features (central obesity, dyslipidemia [high triglycerides, low HDL], hypertension, and IFG) is considered sufficient to diagnose the syndrome.1–3 Twenty-four percent of US adults have the MetS and the prevalence increases with age (44% at 60 years of age).4

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2

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Stastical analysis indication diabetes mellitus .generative ai
5 mins

Trending Topic
Developed by Touch
Mark CompleteCompleted
BookmarkBookmarked

Forty-four Years of the UK Prospective Diabetes Study: Legacy Effect and Beyond

Saptarshi Bhattacharya, Sanjay Kalra, Lakshmi Nagendra

Very few trials in the history of medical science have altered the treatment landscape as profoundly as the UK Prospective Diabetes Study (UKPDS). Even 44 years after its inception, the trial and post-study follow-up findings continue to fascinate and enlighten the medical community. The study was conceived at a time when there was uncertainty about […]

touchREVIEWS in Endocrinology. 2024;21(1):1–2:Online ahead of journal publication
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