Paediatric Endocrinology

Article highlights Lavender and tree tea oils have in vitro oestrogenic and antiandrogenic activity. It has been postulated that these oils may cause prepubertal gynaecomastia and premature thelarche. The association is based on a small number patients (N=12) described in five publications. Based upon the amount of dermal penetration of the oils or their constituents and the […]

Hypothyroidism usually presents with subtle signs and symptoms. Rarely, longstanding juvenile hypothyroidism can manifest as a syndromic diagnosis of Van Wyk–Grumbach syndrome (VWGS).1 VWGS presents as early menarche, thelarche, galactorrhoea, delayed bone ageing and multi-cystic ovaries, along with long-standing primary hypothyroidism.2 Reversal to the prepubertal state is typically seen following the appropriate treatment with levothyroxine. The present […]

The development of effective therapies for the management of cancer in childhood has led to outstanding improvements in survival over the past decades. With this, a growing population of childhood cancer survivors are subject to long-term sequelae impacting on health. Endocrine disorders, and especially reproductive function in adulthood, have become an important concern.1 There is a […]