touchFEATURE
Early Identification of Patients At Risk for MASH With Fibrosis
Overview
Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are characterized by the presence of hepatic steatosis and cardiometabolic risk factors.1,2 When identified early, MASLD and MASH can be managed via multidisciplinary care and may be reversible.3,4 However, when left untreated, these conditions can be progressive and lead to liver damage in select patients.5,6 Despite the importance of early diagnosis, MASLD and MASH are commonly diagnosed late.7 In this activity, watch leading experts discuss the consequences of not identifying MASLD and MASH early, and how to screen patients at-risk of disease progression.
Learning Objectives
After watching this activity, participants should be better able to:
- Outline the importance of patient screening and making an early diagnosis of MASLD/MASH
- Describe which patient groups are at risk for MASLD/MASH
- Understand how to assess patients with MASLD/MASH who are at risk of disease progression including how to optimize disease management and periodic testing
To view more resources, please click below (external site).
ALD, alcohol-related liver disease
MASLD, metabolic dysfunction-associated steatotic liver disease
MASH, metabolic dysfunction-associated steatohepatitis
NASH, non-alcoholic steatohepatitis
References
- Rinella ME et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966-1986.
- Rinella ME et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-1835.
- Cusi K et al. American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD). Endocr Pract. 2022;28(5):528-562.
- Vilar-Gomez E et al. Gastroenterology. 2015;149(2):367-78.e5.
- Canbay A et al. Patterns and predictors of mortality and disease progression among patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2020;52(7):1185-1194.
- Loomba R et al. Nonalcoholic fatty liver disease progression rates to cirrhosis and progression of cirrhosis to decompensation and mortality: a real world analysis of Medicare data. Aliment Pharmacol Ther. 2020;51(11):1149-1159.
- Charlton M et al. The clinical and economic burdens of metabolic dysfunction-associated steatohepatitis. J Med Econ. 2024;27(1):919-930.
Faculty information and downloadable resources are available in the Toolkit: The MASH Quick Reference Guide
Taking proactive steps to identify and screen patients at risk for MASH can help improve patient outcomes.2,3 Learn what MASH is, who is at the highest risk of developing MASH, and how to know if your patient has MASH with clinically significant fibrosis.Smashing MASH Myths
Myths and misconceptions about metabolic dysfunction-associated steatohepatitis (MASH) can hinder timely diagnosis and effective management of patients. SMASHing these myths and increasing awareness is important to help improve patient outcomes through prompt screening, identification, and effective management considerations.3
Faculty information and downloadable resources are available in the Toolkit: The MASH Quick Reference Guide
Taking proactive steps to identify and screen patients at risk for MASH can help improve patient outcomes.2,3 Learn what MASH is, who is at the highest risk of developing MASH, and how to know if your patient has MASH with clinically significant fibrosis.Smashing MASH Myths
Myths and misconceptions about metabolic dysfunction-associated steatohepatitis (MASH) can hinder timely diagnosis and effective management of patients. SMASHing these myths and increasing awareness is important to help improve patient outcomes through prompt screening, identification, and effective management considerations.3
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