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Saptarshi Bhattacharya, Sanjay Kalra, Lakshmi Nagendra

Very few trials in the history of medical science have altered the treatment landscape as profoundly as the UK Prospective Diabetes Study (UKPDS). Even 44 years after its inception, the trial and post-study follow-up findings continue to fascinate and enlighten the medical community. The study was conceived at a time when there was uncertainty about […]

Mads Krogsgaard Thomsen, ADA 2019 – PIONEER studies

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Published Online: Jun 26th 2019

It was an honor to meet Professor Mads Krogsgaard Thomsen to discuss the results from seven phase 3a PIONEER clinical trials for oral semaglutide in patients with type 2 diabetes, including the cardiovascular outcomes trial (PIONEER 6) at the highly anticipated symposium highlighted by the ADA 2019 annual meeting.

Filmed at the American Diabetes Association (ADA) annual meeting 2019, San Francisco, USA

Questions:
1. What are the advantages of oral semaglutide compared to existing glucagon-like peptide-1 (GLP-1) analogues? (0:05)
2. Could you give us an overview on the data on oral semaglutide that are being presented at this meeting? (0:36)
3. What were the findings of oral semaglutide on weight loss? (1:37)
4. The PIONEER studies investigated a number of combined therapeutic approaches. Which were the most promising? (2:24)
5. Which patients are most likely to benefit from oral semaglutide? (3:12)

Professor Mads Krogsgaard Thomsen has no conflicts of interest in relation to this video.

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