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Hyponatraemia is primarily a disorder of water balance or distribution, characterized by serum sodium (Nas) levels less than 135 mmol/L.1 Hyponatraemia is the most common electrolyte disorder among elderly patients and is associated with increased mortality rates and longer hospital stays.2–4 The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a frequent cause of hyponatraemia in […]

Mads Krogsgaard Thomsen, ADA 2019 – PIONEER studies

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Published Online: Jun 26th 2019

It was an honor to meet Professor Mads Krogsgaard Thomsen to discuss the results from seven phase 3a PIONEER clinical trials for oral semaglutide in patients with type 2 diabetes, including the cardiovascular outcomes trial (PIONEER 6) at the highly anticipated symposium highlighted by the ADA 2019 annual meeting.

Filmed at the American Diabetes Association (ADA) annual meeting 2019, San Francisco, USA

Questions:
1. What are the advantages of oral semaglutide compared to existing glucagon-like peptide-1 (GLP-1) analogues? (0:05)
2. Could you give us an overview on the data on oral semaglutide that are being presented at this meeting? (0:36)
3. What were the findings of oral semaglutide on weight loss? (1:37)
4. The PIONEER studies investigated a number of combined therapeutic approaches. Which were the most promising? (2:24)
5. Which patients are most likely to benefit from oral semaglutide? (3:12)

Professor Mads Krogsgaard Thomsen has no conflicts of interest in relation to this video.

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