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Saptarshi Bhattacharya, Sanjay Kalra, Lakshmi Nagendra

Very few trials in the history of medical science have altered the treatment landscape as profoundly as the UK Prospective Diabetes Study (UKPDS). Even 44 years after its inception, the trial and post-study follow-up findings continue to fascinate and enlighten the medical community. The study was conceived at a time when there was uncertainty about […]

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Carol Wysham, ADA 2022: Tirzepatide for type 2 diabetes, post-hoc analysis of the SURPASS trials

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Published Online: Jul 1st 2022

The SURPASS trials demonstrated the efficacy and safety of tirzepatide for type 2 diabetes. Dr Carol Wysham (MultiCare Rockwood Clinic, Spokane, WA, USA) discusses the outcomes of a post-hoc analysis of the SURPASS programme and the impact of tirzepatide on clinical practice following its recent FDA approval.

The abstract entitled ‘Effect of Once-Weekly TZP on Glycemic Control by Baseline Age in Patient Subpopulations from the SURPASS Trials was presented at the 82nd American Diabetes Association Scientific Session, June 3-7, 2022.

Questions

  1. What has the SURPASS clinical trial programme taught us about the efficacy and safety of tirzepatide in the treatment of patients with type 2 diabetes? (0:25)
  2. Which subpopulations were evaluated in the post-hoc analysis you are presenting? (1:25)
  3. What were the findings of these analyses? (1:56)
  4. What is the safety profile of tirzepatide? (2:46)
  5. Following the recent FDA approval of tirzepatide, what do you expect to be its impact on clinical practice? (3:40)

Disclosures: Carol Wysham has received grant/research support from Abbott, Corcept, Eli Lilly, Novo Nordisk, Regeneron and Vanda.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ADA 2022.

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