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Hyponatraemia is primarily a disorder of water balance or distribution, characterized by serum sodium (Nas) levels less than 135 mmol/L.1 Hyponatraemia is the most common electrolyte disorder among elderly patients and is associated with increased mortality rates and longer hospital stays.2–4 The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a frequent cause of hyponatraemia in […]

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Carol Wysham, ADA 2022: Tirzepatide for type 2 diabetes, post-hoc analysis of the SURPASS trials

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Published Online: Jul 1st 2022

The SURPASS trials demonstrated the efficacy and safety of tirzepatide for type 2 diabetes. Dr Carol Wysham (MultiCare Rockwood Clinic, Spokane, WA, USA) discusses the outcomes of a post-hoc analysis of the SURPASS programme and the impact of tirzepatide on clinical practice following its recent FDA approval.

The abstract entitled ‘Effect of Once-Weekly TZP on Glycemic Control by Baseline Age in Patient Subpopulations from the SURPASS Trials was presented at the 82nd American Diabetes Association Scientific Session, June 3-7, 2022.

Questions

  1. What has the SURPASS clinical trial programme taught us about the efficacy and safety of tirzepatide in the treatment of patients with type 2 diabetes? (0:25)
  2. Which subpopulations were evaluated in the post-hoc analysis you are presenting? (1:25)
  3. What were the findings of these analyses? (1:56)
  4. What is the safety profile of tirzepatide? (2:46)
  5. Following the recent FDA approval of tirzepatide, what do you expect to be its impact on clinical practice? (3:40)

Disclosures: Carol Wysham has received grant/research support from Abbott, Corcept, Eli Lilly, Novo Nordisk, Regeneron and Vanda.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ADA 2022.

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