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Thyroid gland inside human body. 3D illustration
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Thyroid eye disease (TED), also known as Graves’ orbitopathy, is a complex autoimmune disorder driven by an interplay of immune cells, orbital fibroblasts and tissue remodelling factors that lead to inflammation, oedema and, ultimately, potential vision loss.1 While the disease has historically been challenging to manage, recent therapeutic innovations are reshaping treatment paradigms and offering new […]

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Hypercalcaemia is a common clinical condition in hospitalized patients. Malignancies and primary hyperparathyroidism (PHPT) are the two most common causes of hypercalcaemia in hospitalized patients.1–3 Apparently, there is a changing profile of hypercalcaemia in India, especially in hospital settings, because ...

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Hiya Boro, Harish Sharma, Deepak Mittal

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Welcome to the latest edition of touchREVIEWS in Endocrinology. In this issue we feature a range of articles to keep you up to date with the latest discussions and developments in the field of medical endocrinology. We start with an ...

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Cornelius J Fernandez, Lakshmi Nagendra, Mohammed Alkhalifah

Hypertension affects up to 40% of the adult population worldwide,1 and according to the World Health Organization’s 2021 estimates, globally 1.28 billion adults between 18 and 79 years are affected.2 Of these, 85% have essential hypertension3 and the remainder have secondary hypertension, which is potentially ...

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Parathyroid carcinoma is a rare endocrine neoplasm with an incidence of 0.5–2.0% of all cases of primary hyperparathyroidism (PHPT).1 It was first described in 1904 by de Quevain, when it was found in a patient presenting with a non-functioning parathyroid mass.2 Around 26 ...

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Coverage from: WCO-IOF-ESCEO Highlights

Surgery remains a mainstay of treatment in primary hyperparathyroidism (PHPT), the new guidelines for management provide alternative options for patients in which surgery is contraindicated. We were delighted to speak to Prof. Aliya A. Khan (McMaster University Medical Centre, Hamilton, ...

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Coverage from: WCO-IOF-ESCEO Highlights

Primary hyperparathyroidism (PHPT) is caused by the overproduction of parathyroid hormone (PTH) by the parathyroid gland, the symptoms of which can remain dormant until later in life and as such PHPT is often underdiagnosed. We were delighted to speak to ...

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Hiya Boro, Saurav Khatiwada, Sarah Alam

Renal tubular acidosis (RTA) is characterized by the impaired ability of the kidneys to absorb filtered bicarbonate or to excrete titrable acid in urine.1 It manifests as normal anion gap (hyperchloremic) metabolic acidosis. RTA may be of four types: type 1 (...

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Tuberculosis (TB) is a major public health concern in low- and middle-income countries (LMICs) of Asia and Africa, which have a high burden of human immunodeficiency virus (HIV) infection and malnutrition. It is epidemic in these regions being associated with ...

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Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant endocrine tumour syndrome characterised by three main manifestations which are primary hyperparathyroidism (78–94%), gastroenteropancreatic neuroendocrine tumours (GEP-NETs) (35–78%) and pituitary adenomas (20–65%).1 As described, GEP-NETs are the second most common component of MEN1 syndrome ...

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  Disorders related to bone health are commonly seen in clinical practice in India. The most common conditions are vitamin D deficiency-related disorders (rickets, osteomalacia), followed by osteoporosis, hyperparathyroidism, endocrine osteopathies, and impaired bone health associated with systemic diseases.1–3 Vitamin ...

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According to the estimates of the International Diabetes Federation (IDF), one in every 11 adults of the global population has diabetes, with an overall disease prevalence of 425 million.1 This diabetes prevalence is expected to increase exponentially with time because of the ...

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18F-fluorocholine-positron emission tomography/computerized tomography (FC-PET/CT) has traditionally been used for disease localisation and management in oncology (e.g. hepatocellular carcinoma and prostate cancer).1 Diagnosis of parathyroid adenomas incidentally picked up in patients with malignancy who underwent FC-PET/CT ...

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Case Presentation Sometimes the worst has to happen before seeking medical attention. This was the case of a 42-year-old man who arrived to the emergency room with altered mental status characterised by lethargy and confusion. His sister referred a long-standing ...

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Endocrine myopathies represent disorders of the musculoskeletal system that occur in the following pathological conditions: exogenous and endogenous glucocorticoid excess (steroid myopathy), morbid obesity (sarcopenic obesity), hypogonadism, hypothyroidism, hyperparathyroidism, growth hormone deficiency and type 2 diabetes (diabetic myopathy).1–3 Because sarcopenia is ...

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Primary hyperparathyroidism (PHPT) and cancer-related hypercalcaemia are the most common causes of hypercalcaemia and PHPT is the most common cause of hypercalcaemia in outpatients. An autonomous overproduction of parathyroid hormone (PTH) leading to hypercalcaemia, which is not downregulated by the ...

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Summary An interesting case of persistent hypercalcaemia of primary hyperparathyroidism (pHPT) resistant to medical management for more than 5 years, who demonstrated a dramatic response to the first dose of denosumab with a significant and persistent drop in her level of ...

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It is my pleasure to provide a foreword for this issue of European Endocrinology, which coincides with a landmark 50th annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna. This meeting promises to be a ...

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