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17 Results Found for “melanocortin-4 receptor agonist”
Data presented at ENDO 2026 highlighted investigational approaches for difficult-to-control type 2 diabetes and acquired hypothalamic obesity, real-world outcomes with tirzepatide, and wider health impacts of GLP-1-based therapy.
Post-bariatric weight regain is a major clinical challenge. In the BARI-STEP trial, semaglutide 2.4 mg weekly led to substantial, sustained weight loss and improved cardiometabolic health. Dr Janine Makarondis discusses the findings and the potential of GLP-1 therapy in this patient population.
Cushing’s disease (CD) is caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma, or rarely carcinoma, and is considered a highly morbid endocrine disorder with few medical options.1,2 Although transsphenoidal pituitary surgery (TSS) is the mainstay of treatment for ...
Obesity defined as abnormal or excessive fat accumulation that presents a risk to health, is a chronic disease linked to metabolic co-morbidities, such as type 2 diabetes mellitus and cardiovascular disease, a reduced life expectancy, economic burden and reduced quality of ...
Cushing’s disease (CD), or pituitary-dependent Cushing’s syndrome, is almost always caused by corticotroph tumours, a type of pituitary neuroendocrine tumour, which overproduces adrenocorticotrophic hormone (ACTH), ultimately leading to hypercortisolism and its associated clinical consequences, including increased mortality.1 The ...
Pituitary adenomas are benign tumours that arise from the adenohypophysis. They are the second most frequent intracranial tumour type after meningiomas, and account for 16.2% of all primary cranial neoplasms.1 Though likely an underestimate, the incidence of pituitary adenomas is approximately ...
Obesity is a complex and multifactorial condition caused by various behavioral and environmental factors, socioeconomic background, and genetic susceptibility. The leptin-melanocortin system has a well-established role in energy homeostasis and deficiencies of the vital molecules of the pathway due to ...
The growing prevalence of obesity is a global health concern. In 2009 to 2010, more than one-third of adults and 17 % of youth in the US were obese, as defined by body mass index (BMI). Obesity is associated with numerous health risks such ...
Ghrelin is a 28-amino-acid peptide predominantly secreted in the stomach and stimulates appetite and growth hormone (GH) release. The name ghrelin is based on ‘ghre’ a word root in Proto-Indo-European languages meaning ‘grow’ in reference to its ability to stimulate ...
Sustained-release Naltrexone/Bupropion— A Novel Pharmacologic Approach to Obesity and Food Craving
The growing prevalence of obesity is a global health concern. In 2009 to 2010, more than one-third of adults and 17 % of youth in the US were obese, as defined by body mass index (BMI). Obesity is associated with numerous health risks such ...
Physiology of Normal Penile Erection Physiology of Normal Penile ErectionPenile erection is a complex hemodynamic event that involves a combination of local, humoral, and neural factors. A key step in the signaling pathway is the release of NO from nitrergic ...
Although much attention has been given to the study of post-menopause and the options in hormone replacement treatment (i.e. oestrogens and progestins), relatively little attention and awareness has been focused on the activity of endogenous or exogenous androgens in ...
Although much attention has been given to the study of post-menopause and the options in hormone replacement treatment (i.e. oestrogens and progestins), relatively little attention and awareness has been focused on the activity of endogenous or exogenous androgens in ...
When these treatments have failed, drugs represent the next step in therapy, although they do not play a role in primary therapy as in other types of secretory pituitary tumours such as prolactinomas or acromegaly. However, their utility is reflected ...
Physiology of Normal Penile Erection Physiology of Normal Penile ErectionPenile erection is a complex hemodynamic event that involves a combination of local, humoral, and neural factors. A key step in the signaling pathway is the release of NO from nitrergic ...
Central Nervous System Targets Central Nervous System Targets At the level of the central nervous system (CNS), neurotransmitters and their receptors and neuronal pathways represent molecular targets that may be exploited for the purpose of treating ED. Prominent among these ...
The ideal drug for Cushing’s disease that targets the pituitary has not been found. Variable compounds with neuromodulatory properties, including dopamine agonists and somatostatin analogues, gamma-aminobutyric acid (GABA) agonists, serotonin antagonists and different nuclear hormone receptor ligands involved in ...
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