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Cushing’s disease (CD) is caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma, or rarely carcinoma, and is considered a highly morbid endocrine disorder with few medical options.1,2 Although transsphenoidal pituitary surgery (TSS) is the mainstay of treatment for ...
Gestational diabetes mellitus (GDM) is generally defined as “any degree of glucose tolerance with onset or first recognition during pregnancy”.1 It currently is one of the diseases with the highest morbidity among pregnant women.2 Determining its prevalence has been a ...
Cushing’s disease (CD), or pituitary-dependent Cushing’s syndrome, is almost always caused by corticotroph tumours, a type of pituitary neuroendocrine tumour, which overproduces adrenocorticotrophic hormone (ACTH), ultimately leading to hypercortisolism and its associated clinical consequences, including increased mortality.1 The ...
Pituitary tumours (PTs) are located in the sella turcica, which surrounds the adenohypophysis and neurohypophysis. PTs range from asymptomatic incidentalomas to symptomatic aggressive neoplasms, such as invasive neoplasms or pituitary carcinomas.1 Symptomatic lesions can be characterized either by hormonal overproduction ...
Diabetes mellitus is a chronic disease that affects many people around the world. Sedentary lifestyle is considered a main risk factor for type 2 diabetes mellitus (T2DM). As presented in this editorial, the advantages of activity in preventing and treating ...
We caught up with Dr Mathias Ried-Larsen (Centre for Physical Activity Research, Rigshospitalet) to discuss the results of his study into the effects of cycling on all-cause and cardiovascular mortality among people with diabetes. Questions Tell us about your study ...
Obesity, defined as the presence of excess body fat, is a major public health problem which appears to have become endemic to the human race.1 Owing to its multifactorial etiopathogenesis, clinical manifestations and comorbidities, the management of obesity can be ...
Pituitary adenomas are benign tumours that arise from the adenohypophysis. They are the second most frequent intracranial tumour type after meningiomas, and account for 16.2% of all primary cranial neoplasms.1 Though likely an underestimate, the incidence of pituitary adenomas is approximately ...
Exercise is essential to health and well-being. For people with type 1 diabetes (T1D), it also improves longevity, and decreases the risk of diabetes-related complications. Unfortunately, due to the use of exogenous insulin that stays in circulation substantially longer than ...
Subclinical hypothyroidism (SH), sometimes referred to as mild hypothyroidism, is a cumbersome term used to describe the compensatory increase in thyroid-stimulating hormone (TSH) levels to preserve normal thyroid hormone levels before they fall below normal, thus averting thyroid gland failure. ...
Women with gestational diabetes mellitus (GDM) carry a multidimensional and trans-generational impact.1 It poses a huge medical and public health burden on society today, which can be mitigated if appropriate proactive and preventive strategies are put in place. These include ...
Subclinical hypothyroidism (SH), sometimes referred to as mild hypothyroidism, is a cumbersome term used to describe the compensatory increase in thyroid-stimulating hormone (TSH) levels to preserve normal thyroid hormone levels before they fall below normal, thus averting thyroid gland failure. ...
Arterial Stiffness and Cardiovascular Risk Recently, much emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. In fact, increased arterial wall rigidity has been acknowledged as a major independent risk factor for cardiovascular ...
Primary hyperparathyroidism (PHPT) and cancer-related hypercalcaemia are the most common causes of hypercalcaemia and PHPT is the most common cause of hypercalcaemia in outpatients. An autonomous overproduction of parathyroid hormone (PTH) leading to hypercalcaemia, which is not downregulated by the ...
Arterial Stiffness and Cardiovascular Risk Arterial Stiffness and Cardiovascular Risk Recently, much emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. In fact, increased arterial wall rigidity has been acknowledged as a major ...
For several decades human body weight has been increasing worldwide to a point where the prevalence of overweight and obese adults and children has been described as epidemic or even pandemic.1–6 The statistics are alarming: in 2005 1.6 billion people worldwide were ...
According to the American Cancer Society, in 2013 there will be an estimated 1,660,290 new cancer cases and 580,350 deaths from cancer. Lung, colorectal, breast and prostate cancer are the most common malignancies in the US, accounting for approximately 50 % of new cancer diagnoses. ...
Changes in lifestyle and eating behavior in humans over the last century have contributed significantly to the epidemic of obesity and an associated dramatic increase in the incidence of diabetes worldwide (Zimmet, Alberti et al. 2001).Type 2 diabetes accounts for more ...
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