McCune–Albright syndrome (MAS) is a genetic disorder first described by McCune1 and Albright2  in the 1930s as a triad of polyostotic fibrous dysplasia, café-au-lait spots, and precocious puberty (Figure 1). Since then, other hyperfunctioning endocrinopathies have been described in ...

Welcome to the summer edition of US Endocrinology. In this issue we present authoritative, up-to-date information on a wide range of salient topics. The pandemic of obesity is driving the diabetes epidemic across the globe, with developing countries especially bearing ...

The pituitary gland, or hypophysis, is the ‘master gland’ that secretes multiple hormones which regulate the functioning of other endocrine organs, such as the thyroid, adrenal cortex and gonads. Though none of the major pituitary hormones directly control the endocrine ...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant endocrine tumour syndrome characterised by three main manifestations which are primary hyperparathyroidism (78–94%), gastroenteropancreatic neuroendocrine tumours (GEP-NETs) (35–78%) and pituitary adenomas (20–65%).1 As described, GEP-NETs are the second most common component of MEN1 syndrome ...

Pituitary adenomas are benign tumours that arise from the adenohypophysis. They are the second most frequent intracranial tumour type after meningiomas, and account for 16.2% of all primary cranial neoplasms.1 Though likely an underestimate, the incidence of pituitary adenomas is approximately ...

  Welcome to the latest edition of European Endocrinology, which features a range of articles describing current practices and research that directly affect endocrinologists, as well as being of interest to the wider biomedical community. Diabetes is the focus of ...

Acromegaly is a chronic disorder characterised by growth hormone (GH) hypersecretion, predominantly caused by a pituitary adenoma.1 Disease prevalence ranges from 2.8–13.7 cases and annual incidence is between 0.2–1.1 cases/100,000 people; however, real incidence is likely much higher.2,3 Average age at diagnosis ...

Growth/growth hormone/insulin-like growth factors Evidence has long supported insulin-like growth factor-2 (IGF-2) as an important fetal growth factor. Begemann and co-workers from Germany and the Netherlands report four patients from a multigenerational family with the combination of severe ...

Acromegaly is an uncommon disorder that, in the vast majority of cases, is the result of a growth hormone (GH)-secreting pituitary adenoma. Because tumors are often macroadenomas at the time of diagnosis, there may be a number of signs ...